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Understanding the sentinel lymph node

A single node
to stage the entire axilla

The sentinel lymph node is the first lymphatic relay draining the tumour. If it is free of tumour cells, the probability that deeper nodes are involved is very low. This technique therefore allows precise assessment of the axilla while sparing the vast majority of patients a heavier procedure — axillary dissection.

If tumour cells travel, they follow a precise path through the lymphatic network. They pass first through a relay node under the arm — the "sentinel". By removing it alone, we assess the axilla reliably without removing all the nodes. With dissection (10 to 20 nodes), the risk of lymphoedema is 20 to 30%. With sentinel node biopsy (1 to 3 nodes), it drops to 5 to 7%.

Major turning point: until the 2010s, an involved node automatically meant dissection. No longer. The ACOSOG Z0011, AMAROS, SENOMAC trials have shown that it can be replaced by radiotherapy extended to all nodal regions — same outcomes, far fewer sequelae. This is axillary de-escalation.

What sentinel node biopsy does not replace. It assesses the axilla, but does not treat the tumour (lumpectomy or mastectomy, during the same operation). Adjuvant treatments (radiotherapy, endocrine therapy, chemotherapy) are decided at the multidisciplinary team meeting.

>95 %
Detection rate
The sentinel node is identified in more than 95% of cases.
5–7 %
Lymphoedema risk
Versus 20 to 30% after dissection.
1–3
Nodes harvested
Versus 10 to 20 in full dissection. Scar 2–4 cm.
Who is it for?

Who benefits from
sentinel lymph node biopsy

Sentinel lymph node biopsy is offered to the vast majority of women undergoing surgery for an invasive breast cancer, provided the axilla is clinically reassuring (no palpable or suspicious node). It is also recommended in cases of mastectomy for ductal carcinoma in situ (DCIS), where an invasive focus may be found on the final pathology. In some highly favourable situations, it is now possible to skip sentinel node biopsy altogether.

Can we skip sentinel node biopsy?

Since 2023–2024, yes — for very carefully selected patients. The Italian SOUND trial (JAMA Oncology, 2023) compared, in women with a small invasive cancer (≤ 2 cm) and normal axillary ultrasound: standard sentinel node biopsy versus complete omission. At 5 years, no difference in survival or recurrence. The American INSEMA trial (NEJM, 2025) confirms.

Omission can be discussed when several criteria are met: post-menopausal, ductal invasive cancer, small tumour, impeccable axillary ultrasound, luminal A biological profile. The patient is then spared the axillary scar and even the small risk of lymphoedema.

Not yet a universal standard. Omission remains an option discussed case by case, validated at the multidisciplinary team meeting. For every other situation, sentinel node biopsy remains the reference approach.

After neoadjuvant chemotherapy?

When chemotherapy is given before surgery, the TAD technique (Targeted Axillary Dissection) allows, post-chemo, to harvest both the standard sentinel node and the initially suspicious node — located thanks to a small metallic clip deposited before treatment. If both are disease-free, we stop there — no dissection. If still involved, the next step (dissection, axillary radiotherapy) is decided at the multidisciplinary team meeting.

Conversely, an upfront dissection is performed when nodal involvement is proven before surgery (positive cytology or core biopsy) or in inflammatory breast cancer. DCIS treated by lumpectomy or prophylactic mastectomy (BRCA carriers) do not warrant sentinel node biopsy.

The decision is always made at the multidisciplinary team meeting — not by the surgeon alone. It is based on the complete file: tumour size and type, axillary imaging, biological profile, age, menopausal status. The trend: do as little as possible whenever scientific evidence allows.

Scientific sources 5 references +

Gentilini OD, Botteri E, et al. Sentinel Lymph Node Biopsy vs No Axillary Surgery (SOUND trial). JAMA Oncology, 2023;9(11):1557–1564.

Reimer T, Stachs A, et al. Axillary Surgery in Breast Cancer — INSEMA Trial. NEJM, 2025;392(13):1189–1200.

Caudle AS, Yang WT, et al. Targeted Axillary Dissection (TAD). J Clin Oncol, 2016;34(10):1072–1078.

SENORIF 2025–2026 Guidelines — Île-de-France Breast Centres Network.

ASCO Sentinel Lymph Node Biopsy Guideline Update, 2021 — Lyman GH et al. J Clin Oncol, 2021;39(27):3056–3082.

How it works

How it works,
in practice

Sentinel node biopsy involves two steps. First, we "mark" the node so it can be located precisely in the operating room. Then, we harvest it during surgery, at the same time as the breast procedure (lumpectomy or mastectomy). The axillary step itself is quick — 5 to 10 minutes — and is added to the duration of the breast surgery. Admission is most often same-day (outpatient).

01
Mapping
Technetium injected the day before or the morning of surgery.
02
Dye
Patent blue or indocyanine green in the OR for precision.
03
Harvest
2–4 cm incision, 1 to 3 nodes, 5–10 minute step.
04
Result
Pathology in 10–15 days, explained at follow-up.

Analysis and next steps

The node is analysed by pathology. Final result in 10 to 15 days, explained at a post-operative consultation. Next step depends on findings:

  • No tumour cells (most common): no further procedure.
  • Small involvement (isolated cells or micrometastasis): no dissection. Planned radiotherapy is sufficient.
  • More significant involvement (macrometastasis): dissection is no longer automatic. Thanks to ACOSOG Z0011, AMAROS, SENOMAC, it can be replaced by radiotherapy extended to all nodal regions — same outcomes, fewer side effects. Decision at the multidisciplinary team meeting.

Mapping by technetium (day before or morning of surgery), with optional patent blue dye or indocyanine green in the OR, offers a detection rate above 95%. The axillary step is performed in 5 to 10 minutes, under general anaesthesia, through a 2 to 4 cm incision under the arm (1 to 3 nodes harvested).

Anaesthesia

General anaesthesia, at the same time as the breast surgery. Mandatory anaesthesia consultation 48 h before. Report any allergy history.

Duration & stay

Axillary step: 5 to 10 minutes, added to the breast surgery. Admission most often outpatient.

Coverage

100% of the French Social Security base rate (ALD framework for breast cancer). Supplementary fees apply (secteur 2) — detailed quote at consultation.

When dissection remains necessary

What if an axillary
dissection is necessary?

Axillary dissection — removal of all the nodes under the arm — is sometimes still necessary, in specific, well-defined situations. Here is when, how, and how to limit its long-term sequelae.

Sentinel node biopsy
Targeted, minimal sequelae
1 to 3 nodes harvested
2 to 4 cm scar
5–7 % lymphoedema risk
Day-case in most situations
No drain, no compression sleeve
Axillary dissection
More extensive, stricter care
10 to 20 nodes harvested
5 to 8 cm scar
20–30 % lymphoedema risk
1 to 2 nights hospital stay
Drain + 2-month sleeve

When is dissection proposed?

Three main situations:

  • Node proven to be involved before surgery (positive fine-needle aspiration or core biopsy).
  • Inflammatory breast cancer.
  • Sentinel node mapping failure in the OR — a rare situation where the node cannot be identified despite tracer and dye.

Outside of these cases, we never convert a sentinel node biopsy into a dissection mid-surgery if the sentinel node was properly identified. Any subsequent decision (most often extended radiotherapy) is made later, at the multidisciplinary team meeting.

How it works

Under general anaesthesia, at the same time as the breast surgery. Removal of all the fatty tissue containing the axillary nodes (10 to 20 nodes). Axillary step: 20 to 30 minutes. Scar of 5 to 8 cm under the arm. A drain is usually left for a few days — hospital stay of 1 to 2 nights.

Possible sequelae

  • Arm lymphoedema ("swollen arm"): 20 to 30%, sometimes permanent.
  • Chronic pain and pulling sensations under the arm.
  • Reduced shoulder mobility.
  • Altered sensation (numbness, tingling), often partial.
  • Increased vulnerability to infection (risk of erysipelas from minor wounds).

The compression sleeve: systematic prevention

After dissection, prescription of a compression sleeve is systematic. A soft, discreet compressive garment that supports lymphatic flow.

Protocol: systematic wear for 2 months post-operatively (highest-risk period). Beyond that, worn on flights (pressurisation = lymphatic stagnation) and during unusual physical effort. If lymphoedema develops, the sleeve becomes curative: daily wear + specialised manual lymphatic drainage physiotherapy.

The sleeve is not prescribed after sentinel node biopsy alone — risk too low.

Seek advice quickly in case of swelling of the arm/hand/fingers, heaviness, unusual redness or warmth. Lymphoedema caught early responds far better: manual lymphatic drainage + compression give excellent results when intervention is prompt.

Recovery & precautions

After surgery
— what you need to know

The first weeks

Scar under the arm of 2 to 4 cm (sentinel) or 5 to 8 cm (dissection). Moderate pain, standard painkillers. Simple dressing for a few days, showering allowed the day after.

Numbness or tingling on the inner arm is normal (stretching of a small sensory nerve). Sensation recovers over a few months, faster after sentinel node biopsy.

An axillary web syndrome (taut fibrous cords under the arm limiting movement) may appear at 2–6 weeks. Benign, common (10–20%), responds well to physiotherapy.

Return to normal activities: 2 to 3 weeks (sentinel) or 3 to 4 weeks (dissection). Progressive return to sports depending on healing.

Useful precautions

Goal: limit lymphoedema risk without falling into the opposite extreme. Use your arm normally — regular physical activity prevents lymphoedema, it does not worsen it.

On the operated side:

  • Avoid blood draws, blood pressure measurements, injections.
  • Prevent injuries (gloves for gardening/dishes), disinfect small wounds.
  • Watch for insect bites — seek advice if redness or warmth.

After dissection: sleeve 2 months systematically, then on flights and unusual physical effort. Becomes curative (daily wear + physiotherapy) if lymphoedema develops.

After sentinel node alone: no sleeve (risk too low).

Seek advice quickly in case of swelling, heaviness, unusual redness or warmth.

Frequently asked questions

Your questions about the
sentinel lymph node

Principle
What exactly is the sentinel lymph node?

It is the first node in the axilla toward which lymph from the breast is directed. If it is free of tumour cells, the probability that deeper nodes are involved is very low. By removing it alone, we obtain reliable information about the axilla without removing all the nodes — sparing most patients the long-term sequelae of dissection.

First lymphatic relay Reliability > 95% Avoids dissection
Dissection
Does sentinel node biopsy always avoid dissection?

In the vast majority of cases, yes. Even when a sentinel node is found to be involved (micrometastasis or one to two macrometastases), dissection can usually be avoided — in favor of radiotherapy extended to all nodal regions (axillary, supraclavicular, internal mammary). This is the major takeaway of the landmark trials of the past fifteen years (ACOSOG Z0011, AMAROS, SENOMAC). Dissection remains indicated when a node is proven involved before surgery, in inflammatory breast cancer, or in case of sentinel node mapping failure in the operating room.

Extended radiotherapy rather than dissection Ongoing de-escalation Tumour board decision
Lymphoedema
What is the risk of lymphoedema (swollen arm)?

After sentinel node biopsy alone: 5 to 7%. After dissection: 20 to 30%. A few simple precautions help limit this risk. After dissection, a compression sleeve is systematically prescribed and worn for 2 months post-operatively, then in at-risk situations (flights, unusual physical effort). If lymphoedema develops later, the sleeve becomes curative and is worn daily, with lymphatic drainage physiotherapy.

Sentinel: 5–7% Dissection: 20–30% Sleeve systematic for 2 months after dissection
Tracer
Is the radioactive tracer dangerous?

No. The dose used is very low, less than that of a chest CT scan, and eliminated within 24 hours. The injection is quick and painless. No specific precautions are required for your family — including young children or pregnant women.

Very low radiation Eliminated in 24 h No precautions needed
Dye
Why might my urine turn blue-green after the operation?

If patent blue was used in the OR, it is eliminated by the kidneys for 24 to 48 hours — urine may take a blue-green tint, and the breast may stay slightly bluish for a few weeks at the injection site. This is normal and harmless. An alternative, indocyanine green (a fluorescent agent visible under a special OR light), does not cause any lasting discoloration.

Transient discoloration Harmless Alternative: indocyanine green
Chemo
What about after chemotherapy given before surgery?

It depends on the imaging performed after chemotherapy. If no node looks suspicious any longer on ultrasound or MRI, TAD (Targeted Axillary Dissection) can be performed: the standard sentinel node is harvested together with the node that was originally suspicious — located thanks to a small metallic clip placed by the radiologist before chemotherapy. Conversely, if a node is still suspicious after chemotherapy, dissection is performed directly.

TAD if imaging is reassuring Dissection if node still suspicious Clip to locate in the OR
Results
When will I get the final results?

The full result of the node analysis is available 10 to 15 days after surgery. It is combined with the analysis of the tumour itself (size, grade, biological profile) to build the complete treatment strategy. A post-operative consultation is scheduled to walk you through the full report. If a decision has to be made at the multidisciplinary tumour board, it is explained and discussed with you — never imposed.

Result in 10–15 days Dedicated consultation Shared decision-making
Coverage
Is it reimbursed?

Yes. The lymphoscintigraphy, the surgical procedure and the node analysis are covered at 100% of the French Social Security base rate, under the long-term illness (ALD) framework for breast cancer. Dr Zeitoun practices in secteur 2 non-OPTAM — supplementary fees apply. A detailed quote is provided before any procedure. Your private insurance may reimburse all or part of these supplementary fees depending on your contract.

100% of SS base rate (ALD) Quote at consultation Private insurance may cover

Further reading

Let's discuss
your situation

Every breast cancer is unique. The surgical strategy — sentinel node biopsy alone, combined with a lumpectomy or mastectomy, with or without reconstruction — is built during the consultation, based on your file and your priorities.

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